Yodeah

verb / to know

PREVENTING HEREDITARY CANCER

Learn. Test. Know. Share.

Yodeah is a powerful network of dedicated volunteer professionals committed to saving lives by providing critical knowledge about hereditary cancer and access to affordable, clinical-grade genetic testing.

ABOUT BRCA & OTHER HEREDITARY CANCER GENETIC MUTATIONS

BRCA 1 and BRCA 2 are genes that, when working normally, prevent cancer by repairing DNA. When there is a mutation, these genes don’t work, and cancer is more likely to develop. There are also other genetic mutation in both Ashkenazi and Sephardic Jews that can increase cancer risk, for which closer cancer screening is recommended. Learn more about BRCA and other genes.

WHAT’S YOUR “Y”?

Explore powerful stories and discover your ‘Y’ – why learning, testing, knowing, and sharing are vital in Yodeah’s fight against hereditary cancer. See how lives were transformed through knowledge and affordable genetic testing.

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HOW TO GET TESTED

Testing is easy and affordable. It involves a simple saliva test kit mailed to your home from Color Health, a clinical-grade lab that has also partnered with the American Cancer Society.

We encourage you to learn more before taking the test.

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THE MOST RELEVANT GENES FOR COMMON HEREDITARY CANCERS

* CDK4: analysis is limited to chr12:g.58145429-58145431 (codon 24). EPCAM: analysis is limited to deletions that minimally encompass the 3′ end of the gene including exons 8 and/or 9. GREM1: analysis is limited to duplications that overlap the upstream regulatory region. MITF: analysis is limited to chr3:g.70014091 (including c.952G>A). MUTYH: single heterozygous pathogenic variants, likely pathogenic variants, and variants of uncertain significance are not reported. PMS2: variants of uncertain significance are not reported for exons 12-15. Analysis excludes three variants commonly observed in the pseudogene PMS2CL: c.2182_2184delinsG, c.2243_2246delAGAA and deletion of exons 13-14 (chr7:g.6015768_6018727del). POLD1: analysis is limited to chr19:g.50909713 (including c.1433G>A). POLE: analysis is limited to chr12:g.133250250 (including c.1270C>G).