Yodeah believes in testing for BRCA mutations in all Ashkenazi Jews (men and women) regardless of family history, even if they have only one of four Ashkenazi Jewish grandparents. This is called population-based testing in Ashkenazi Jews. This is supported by extensive medical literature as well as guidelines per National Comprehensive Cancer Network (NCCN.org).
Some information you should know before you test:
- This testing is for a cancer susceptibility gene, not for cancer itself. If you carry a hereditary cancer susceptibility gene such as BRCA, it does not mean you will develop cancer, but your risks of certain cancers are elevated. There are, however, established guidelines to decrease cancer risks, including increased screening, medicines, and medical procedures.
- The 1 in 40 statistic applies to 3 specific genetic mutations on the BRCA genes. These are called Ashkenazi Jewish founder mutations, and they account for ~ 85% of the BRCA mutations found in Ashkenazi Jews. Sometimes, based on family or personal history, it is important to check for additional genetic mutations on a BRCA gene or other cancer-associated genes.
- Guidelines do not recommend testing for a BRCA genetic mutation until age 25, unless there is a family history of cancer at a younger age. This is in part because increased screening for BRCA associated cancers doesn’t begin until age 25. However, if there is a family history of cancer at a younger age or pediatric cancer, full genetic counseling would be recommended.
- The panel included in our discounted negotiated rate includes full BRCA 1 and 2 testing, not only the three more common Ashkenazi Jewish founder mutations. It also includes other well studied cancer susceptibility genes. Remember we have no financial relationship with these commercial labs.
- For medical decision-making, we recommend medical-grade genetic testing, not testing done through 23andMe or Ancestry. If testing was done through those or similiar organizations, medical guidelines would recommend retesting with a medical-grade test.
- The Genetic Information Nondiscrimination Act (GINA): In 2008, a federal law was enacted called The Genetic Information Nondiscrimination Act (GINA) which prevents health insurance companies from discriminating against individuals who carry genetic mutations, such as those on the BRCA genes. This law has more limited protections for the military. GINA does not cover life, disability or long-term care insurance. These types of insurance are regulated by state laws and the laws vary from state to state. Please review your state law. You may want to consider having these policies in place prior to genetic testing. For additional information about GINA please visit National Human Genome Research Institute
- Florida – For policies entered into or renewed after January 1, 2021, Florida enacted a law to add life, disability, and long-term care insurers to the list of insurers prohibited from using genetic information for insurance purposes. Life and long-term care insurers are still able to access a person’s medical record as part of an application exam and consider a medical diagnosis included in a medical record, even if based on the results of genetic test, but in the absence of a diagnosis of a condition related to genetic information, life, long-term care and disability insurers “may not cancel, limit, or deny coverage or establish differentials in premium rates, based on such information.” Life, long-term care and disability insurers are also prohibited from requiring or soliciting genetic information, using genetic test results, or considering a person’s decision regarding genetic testing for insurance purposes.
- Please see Florida Statutes Section 627.4301 and this article for additional information: Click Here to Learn More
- Your results should be put into the context of your personal and family history. What this means is that if you are negative and have a family history of cancer, your doctor may still suggest following you more closely with enhanced screening.
- Most cancer is sporadic, meaning not related to a hereditary cancer gene like BRCA. It is important to continue cancer screening per medical guidelines.
The information provided does not, and is not intended to, constitute legal advice. It is for general informational purposes only and may not constitute the most up-to-date legal or other information. Readers of this website should contact their attorney to obtain advice with respect to any particular legal matter. No reader, user, or browser of this site should act or refrain from acting on the basis of information on this site without first seeking legal advice from counsel in the relevant jurisdiction. The content is provided “as is”; no representations are made that the content is error-free.
Yodeah’s mission is to educate and facilitate cost-effective testing for hereditary cancer genetic mutations in the Jewish community. Yodeah does not give medical advice. We recommend you contact your health care professional for any questions about cancer or genetic testing. Genetic testing is not a substitute for visits to health care professional for recommended screenings or appropriate follow up.